NSC59984, p53-MDM2 inhibitor

The best NSC59984, p53-MDM2 inhibitor, quick delivery, high quality.

Product price

125 EUR

Product size

5 mg

Product catalog no.

SIH-542-5MG

Fast and secure purchase process

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Safety information

Classification: D2B Toxic Material Causing Other Toxic Effects - Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Hazard statement(s): H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of water. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.

Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

 

Other name

NSC59984, NSC-59984, NSC59984, MLS000737358, SMR000528276, (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one, 803647-40-7, AC1NS9AU, CID 5356520, MLS000737358, 1-Methyl-4-[3-(5-nitro-2-furanyl)-1-oxo-2-propenyl]-piperazine, 1-(4-Methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one

Representative figure legend

Chemical structure of NSC59984 (SIH-542), a p53-MDM2 inhibitor. CAS #: 803647-40-7. Molecular Formula: C12H15N3O4. Molecular Weight: 265.3 g/mol. Chemical structure of NSC59984, a p53-MDM2 inhibitor (SIH-542). CAS # 803647-40-7. Molecular Formula: C12H15N3O4.

 

Scientific context

NSC59984 acts on the mutant p53/MDM2 pathway in tumor cells to restore normal function. It is not cytotoxic in healthy cells.

Primary research fields

Cancer, Cancer Growth Inhibitors, p53/mdm2 Inhibitors

 

Soluble in

Soluble in DMSO (5 mg/ml)

Physical appearance

Yellow to brown powder

 

Description

p53-MDM2 inhibitor

PubMed number

Refer to PubMed

 

Shipping recommendations

Shipped Ambient

Product category

Small Molecules

 

Warning information

Non-hazardous

Tested reactivity

To be tested

 

Tested applications

To be tested

CAS number

803647-40-7

 

Molecular weight

265,3 g/mol

Release date

30/Aug/2016

 

Chemical formula

C12H15N3O4

Product type

Inhibitor

 

Origin

Synthetic

Stock availabilitIn Stock

In Stock

 

PubChem number

5356520

Storage recommendations

-20ºC

 

Country of production

Canada

Net weight (g)

0.005

 

Total weight (kg)

0.25

Purity pourcentage

>98%