The best Nutlin-3, p53/mdm2 inhibitor, quick delivery, high quality.
665 EUR
25 mg
SIH-344-25MG
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Chemical structure of Nutlin-3 (SIH-344), a p53/mdm2 inhibitor. CAS #: 548472-68-0. Molecular Formula: C30H30Cl2N4O4. Molecular Weight: 581.9 g/mol. Chemical structure of Nutlin-3, a p53/mdm2 inhibitor (SIH-344). CAS # 548472-68-0. Molecular Formula: C30H30Cl2N4O4.
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one
Cancer, Apoptosis, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
1. Vassilev et al (2004) Science 303: 844.
Soluble in 100 mM DMSO and Ethanol
p53/mdm2 inhibitor
Refer to PubMed
Shipped Ambient
Small Molecules
Non-hazardous
C30H30Cl2N4O4
To be tested
Yellow solid
To be tested
548472-68-0
581,9 g/mol
6-Jun-2012
Synthetic
Inhibitor
In Stock
216345
-20ºC
Canada
0.025
0.25
>98%