The best NSC-66811, p53/mdm2 inhibitor, quick delivery, high quality.
200 EUR
10 mg
SIH-338-10MG
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Chemical structure of NSC-66811 (SIH-338), a p53/mdm2 inhibitor. CAS #: 6964-62-1. Molecular Formula: C23H20N2O. Molecular Weight: 340.4 g/mol. Chemical structure of NSC-66811, a p53/mdm2 inhibitor (SIH-338). CAS # 6964-62-1. Molecular Formula: C23H20N2O.
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.
2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol, 7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol
Cancer, Apoptosis, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759.
Soluble in 25 mg/ml DMSO
p53/mdm2 inhibitor
Refer to PubMed
Shipped Ambient
Small Molecules
Non-hazardous
To be tested
To be tested
340,4 g/mol
White Solid
6-Jun-2012
6964-62-1
Synthetic
C23H20N2O
Inhibitor
In Stock
248986
-20ºC
Canada
0.25
0.01
>98%