Anti-p53BP1 (Polyclonal), ALEXA Fluor 594

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Product price

489 EUR

Product size

100 microliters

Product catalog no.

GENTObs-2740R-A594

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Background information

p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.

Advisory

Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

 

Synonyms

53 BP1; FLJ41424; MGC138366; p202; p53 binding protein 1; p53 BP1; p53BP1; TP53 BP1; TP53BP1; Tumor protein 53 binding protein 1; Tumor protein p53 binding protein 1; Tumor suppressor p53 binding protein 1; TP53B_HUMAN; tumor protein 53-binding protein, 1.

Cross Reactive Species details

No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.

 

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

 

Storage

Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Antigen Source

KLH conjugated synthetic peptide derived from human p53BP1

 

Modification

No modification has been applied to this antibody

Specificity

This antibody reacts specifically with p53BP1

 

Cross reactive species

Human (Homo sapiens), Mouse (Mus musculus)

Properties

For facs or microscopy Alexa 1 conjugate.

 

Host organism

Rabbit (Oryctolagus cuniculus)

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

 

Type

Conjugated Primary Antibody

Group

Polyclonals and antibodies

 

Also known as

p53BP1 Polyclonal Antibody

Other name

Anti-p53BP1 Polyclonal

 

Purification method

Purified by Protein A.

Clone

Polyclonal Antibodies

 

Applications with corresponding dilutions

IF(IHC-P)(1:50-200)

Clonality

Polyclonal Antibody

 

Conjugated with

ALEXA FLUOR® 594

Conjugated

Alexa conjugate 1

 

Excitation emission

590nm/617nm

Concentration

1ug per 1ul

 

Applications

IF(IHC-P)

Target Protein/Peptide

p53BP1

 

Modification site

None

Gene ID

7158

 

Swiss Prot

N/A

Subcellular locations

N/A