Quick contact, quick delivery, greatests anti-Phospho-p53 (Ser376) Antibody prices.
403 EUR
Phospho-p53 (Ser376) Antibody
A1158-100
p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes involved either in progression through the cell cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the concentration in normal cells, principally due to the increased half-life (4 hrs) compared to that of wild-type (20 min). p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and certain mutations also modulate cytoplasmic/nuclear distribution. p53 downregulates Bcl-2 expression and upregulates Bax expression, but may not always be necessary for apoptosis.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human p53
P53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
The antibody solution should be gently mixed before use
WB; 1:500 – 1:2000, IHC; 1:50 – 1:200
Shelf time: 12 months in temp.: -20 deg.C
Affinity purified
Human, Mouse
Polyclonal
Rabbit IgG
anticorps
gel pack
WB, IH
Liquid
Rabbit
TP53
N/A