p53 (FL-393) Antibody, HRP Conjugated

The best p53 (FL-393) Antibody, HRP Conjugated, quick delivery, high quality.

Product price

350 EUR

Product size

0.1ml

Product catalog no.

bs-8687R-HRP

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Antigen background

p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

Properties

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.

 

Synonyms

LFS1; p53; p53 Cellular Tumor Antigen; p53 Tumor Suppressor; Phosphoprotein p53; TP53; Transformation related protein 53; TRP53; Tumor protein p53; Tumour Protein p53.

Storage conditions

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

 

Crossreactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Specificity

This is a highly specific antibody against p53 FL-393.

 

Long name

p53 (FL-393) Polyclonal Antibody, HRP Conjugated

Purification method

This antibody was purified via Protein A.

 

Recommended dilutions

WB(1:100-1000), IHC-P(1:100-500)

Host Organism

Rabbit (Oryctolagus cuniculus)

 

Source

Full length human p53 protein

Category

Conjugated Primary Antibodies

 

Clone

Polyclonal antibody

Crossreactivity

Human, Mouse, Rat

 

Additional conjugation

HRP Conjugated

Concentration

1ug per 1ul

 

Clonality

Polyclonal

Modification

Unmodified

 

Target Antigen

p53 FL-393

French translation

anticorps

 

Tested applications

WB, IHC-P

Modification site

None

 

Gene ID number

7157

Excitation Emission

N/A

 

Conjugation

HRP