p53 (FL-393) Antibody, Cy5.5 Conjugated

The best p53 (FL-393) Antibody, Cy5.5 Conjugated, quick delivery, high quality.

Product price

350 EUR

Product size

0.1ml

Product catalog no.

bs-8687R-Cy5.5

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Antigen background

p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

Properties

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.

 

Storage conditions

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

Synonyms

LFS1; p53; p53 Cellular Tumor Antigen; p53 Tumor Suppressor; Phosphoprotein p53; TP53; Transformation related protein 53; TRP53; Tumor protein p53; Tumour Protein p53.

 

Crossreactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Conjugated

These antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.

 

Specificity

This is a highly specific antibody against p53 FL-393.

Long name

p53 (FL-393) Polyclonal Antibody, Cy5.5 Conjugated

 

Purification method

This antibody was purified via Protein A.

Host Organism

Rabbit (Oryctolagus cuniculus)

 

Source

Full length human p53 protein

Category

Conjugated Primary Antibodies

 

Clone

Polyclonal antibody

Recommended dilutions

IF(IHC-P)(1:50-200)

 

Crossreactivity

Human, Mouse, Rat

Concentration

1ug per 1ul

 

Additional conjugation

Cy5.5,Cy5.5

Excitation Emission

675nm/694nm

 

Clonality

Polyclonal

Modification

Unmodified

 

Target Antigen

p53 FL-393

Tested applications

IF(IHC-P)

 

French translation

anticorps

Conjugation

Cy5.5

 

Gene ID number

7157

Modification site

None