P53(Ser20) Antibody, Cy5 Conjugated

The best P53(Ser20) Antibody, Cy5 Conjugated, quick delivery, high quality.

Product price

368 EUR

Product size

0.1ml

Product catalog no.

bs-3703R-Cy5

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Antigen background

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Properties

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.

 

Storage conditions

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

Synonyms

P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53

 

Source

KLH conjugated synthetic phosphopeptide derived from human P53 around the phosphorylation site of Ser20

Crossreactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

 

Specificity

This is a highly specific antibody against P53 Ser20.

Long name

P53(Ser20) Polyclonal Antibody, Cy5 Conjugated

 

Purification method

This antibody was purified via Protein A.

Host Organism

Rabbit (Oryctolagus cuniculus)

 

Category

Conjugated Primary Antibodies

Recommended dilutions

IF(IHC-P)(1:50-200)

 

Clone

Polyclonal antibody

Subcellular location

Cytoplasm, Nucleus

 

Crossreactivity

Human, Mouse, Rat

Excitation Emission

625,650nm/670nm

 

Modification

Phosphorylation

Concentration

1ug per 1ul

 

Clonality

Polyclonal

French translation

anticorps

 

Tested applications

IF(IHC-P)

Target Antigen

P53 Ser20

 

Immunogen_range

5-55/393

Swiss Prot

P04637

 

Modification site

Ser20

Additional conjugation

Cy5.5

 

Gene ID number

7157

Conjugation

Cy5