The best TP53 Polyclonal Antibody, quick delivery, high quality.
401 EUR
100 μg
CAC07006
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediatedapoptosis.
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53,TP53,P53
ELISA,WB,IHC. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200
Recombinant human Cellular tumor antigen p53 protein (2-393AA)
Aliquot and store at -20°C. Minimize freezing and thawing.
For research use only. Not for diagnostic procedures.
Caprylic Acid Ammonium Sulfate Precipitation Purified
Polyclonals and antibodies
Please refer to GenBank
Please refer to NCBI
3-7 business days
Human, Mouse
Polyclonal
anticorps
Blue ice
P04637
1 year
Rabbit