p53 (FL-393) Antibody, ALEXA FLUOR 594

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Product price

380 EUR

Product size

100ul

Product catalog no.

bs-8687R-A594

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Background of the antigen

p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

Properties

For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

 

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Synonyms

LFS1; p53; p53 Cellular Tumor Antigen; p53 Tumor Suppressor; Phosphoprotein p53; TP53; Transformation related protein 53; TRP53; Tumor protein p53; Tumour Protein p53.

 

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Long name

p53 (FL-393) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated

 

Specificity

This is a highly specific antibody against p53 FL-393.

Also known as

Anti-p53 FL-393 PAb ALEXA FLUOR 594

 

Host Organism

Rabbit (Oryctolagus cuniculus)

Source

Full length human p53 protein

 

Category

Conjugated Primary Antibodies

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

 

Purification

Purified by Protein A.

Clone

Polyclonal antibody

 

Recommended dilutions

IF(IHC-P)(1:50-200)

Crossreactivity

Human, Mouse, Rat

 

Conjugated with

ALEXA FLUOR® 594

Conjugated

Alexa conjugate 1

 

Excitation emission

590nm/617nm

Concentration

1ug per 1ul

 

Target Antigen

p53 FL-393

Modification

Unmodified

 

Clonality

Polyclonal

French translation

anticorps

 

Tested applications

IF(IHC-P)

Modification Site

None

 

Gene ID Number

7157