anti-p53 (phospho Ser37) Antibody

The best anti-p53 (phospho Ser37) Antibody, quick delivery, high quality.

Product price

180 EUR

Product size

0.1 mg

Product catalog no.

79-448

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Gene info

p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes

Purity

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

 

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Antigen

p53 (Phospho-Ser37) antibody was made against a peptide sequence around phosphorylation site of serine 37 (L-P-S (p) -Q-A) derived from Human p53.

 

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Suspention, pH, azide

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

 

Gene names

P53, BCC7, LFS1, TRP53, GAD, GAD67, Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13, TP53

Spicific to

This antibody detects endogenous level of p53 only when phosphorylated at serine 37.

 

Antibody advice

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Keep at

Store antibody at -20 grades C for up to one year.

 

Immuno application

Western Blot, immuno fluorescence

Antigene name

tumor protein p53

 

Works with

Human, Mouse, Rat

Antibodie's label

unlabelled serum

 

Source

Homo sapiens

Ncbi nr

NP_000537.3

 

Vial with antibody

in solution

Type

Polyclonal

 

Omim nr

120407068

French translation

anticorps

 

Quantity per ml

1 mg/mL

Protein nr

P04637

 

KDa

53 kDa

Ab raised in

Rabbit

 

GENE symbol

TP53

NCBI GENE nr

7157