Quick contact, quick delivery, greatests p53 (Phospho-Ser392) monoclonal antibody prices.
223 EUR
100ug
11-467-C100
The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.
Mouse Monoclonal Antibody against Human p53 (Phospho-Ser392), Clone: FP3.2 [FPS392] is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
*Blaydes JP, Craig AL, Wallace M, Ball HM, Traynor NJ, Gibbs NK, Hupp TR: Synergistic activation of p53-dependent transcription by two cooperating damage_x000D_ recognition pathways. Oncogene. 2000 Aug 10;19(34):3829-39.
at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
The antibody FP3.2 [FPS392] reacts with human p53 tumour suppressor protein phosphorylated at CKII site (Ser 392).
KLH-conjugated phosphopeptide RHKKLMFKTEGPDS[P]D, corresponding to amino acids 378-393 of human p53.
Transcription Regulation & Nuclear Proteins (Human), Transcription Regulation & Nuclear Proteins
Mouse Monoclonal Antibody against Human p53 (Phospho-Ser392), Clone: FP3.2 [FPS392]
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Purified by protein-A affinity chromatography
Monoclonal Antibody (Mab)
purified; unconjugated
p53 (Phospho-Ser392)
Human (Homo sapiens)
> 95% (by SDS-PAGE)
FP3.2 [FPS392]
WB, IHC(P)
anticorps
1 mg/ml