Nutlin-3, p53/mdm2 inhibitor

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Product price

223 EUR

Product size

5 mg

Product catalog no.

SIH-344-5MG

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Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Representative figure legend

Chemical structure of Nutlin-3 (SIH-344), a p53/mdm2 inhibitor. CAS #: 548472-68-0. Molecular Formula: C30H30Cl2N4O4. Molecular Weight: 581.9 g/mol. Chemical structure of Nutlin-3, a p53/mdm2 inhibitor (SIH-344). CAS # 548472-68-0. Molecular Formula: C30H30Cl2N4O4.

 

Safety information

Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes

Scientific context

MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

 

Other name

(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one

Primary research fields

Cancer, Apoptosis, Cancer Growth Inhibitors, p53/mdm2 Inhibitors

 

Bibliography

1. Vassilev et al (2004) Science 303: 844.

Soluble in

Soluble in 100 mM DMSO and Ethanol

 

Description

p53/mdm2 inhibitor

PubMed number

Refer to PubMed

 

Shipping recommendations

Shipped Ambient

Product category

Small Molecules

 

Warning information

Non-hazardous

Chemical formula

C30H30Cl2N4O4

 

Tested reactivity

To be tested

Physical appearance

Yellow solid

 

Tested applications

To be tested

CAS number

548472-68-0

 

Molecular weight

581,9 g/mol

Release date

6-Jun-2012

 

Origin

Synthetic

Product type

Inhibitor

 

Stock availabilitIn Stock

In Stock

PubChem number

216345

 

Storage recommendations

-20ºC

Country of production

Canada

 

Net weight (g)

0.005

Total weight (kg)

0.25

 

Purity pourcentage

>98%