NSC-66811, p53/mdm2 inhibitor

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Product price

665 EUR

Product size

50 mg

Product catalog no.

SIH-338-50MG

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Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Representative figure legend

Chemical structure of NSC-66811 (SIH-338), a p53/mdm2 inhibitor. CAS #: 6964-62-1. Molecular Formula: C23H20N2O. Molecular Weight: 340.4 g/mol. Chemical structure of NSC-66811, a p53/mdm2 inhibitor (SIH-338). CAS # 6964-62-1. Molecular Formula: C23H20N2O.

 

Safety information

Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes

Scientific context

A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.

 

Other name

2-Methyl-7-[Phenyl(phenylamino)meth­yl]-8-quinolinol, 7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol

Primary research fields

Cancer, Apoptosis, Cancer Growth Inhibitors, p53/mdm2 Inhibitors

 

Bibliography

1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759.

Soluble in

Soluble in 25 mg/ml DMSO

 

Description

p53/mdm2 inhibitor

PubMed number

Refer to PubMed

 

Shipping recommendations

Shipped Ambient

Product category

Small Molecules

 

Warning information

Non-hazardous

Tested reactivity

To be tested

 

Tested applications

To be tested

Molecular weight

340,4 g/mol

 

Physical appearance

White Solid

Release date

6-Jun-2012

 

CAS number

6964-62-1

Origin

Synthetic

 

Chemical formula

C23H20N2O

Product type

Inhibitor

 

Stock availabilitIn Stock

In Stock

PubChem number

248986

 

Storage recommendations

-20ºC

Country of production

Canada

 

Total weight (kg)

0.25

Net weight (g)

0.05

 

Purity pourcentage

>98%