Anti-ASPP2/p53BP2 (Polyclonal), ALEXA Fluor 594

The best Anti-ASPP2/p53BP2 (Polyclonal), ALEXA Fluor 594, quick delivery, high quality.

Product price

489 EUR

Product size

100 microliters

Product catalog no.

GENTObs-1283R-A594

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Background information

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

Advisory

Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

 

Cross Reactive Species details

No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

 

Synonyms

BBP; 53BP2; ASPP2; P53BP2; PPP1R13A; Apoptosis-stimulating of p53 protein 2; Bcl2-binding protein; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; p53-binding protein 2; TP53BP2

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

 

Storage

Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Cross reactive species

Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)

 

Antigen Source

KLH conjugated synthetic peptide derived from human ASPP2

Specificity

This antibody reacts specifically with ASPP2/p53BP2

 

Modification

No modification has been applied to this antibody

Properties

For facs or microscopy Alexa 1 conjugate.

 

Also known as

ASPP2/p53BP2 Polyclonal Antibody

Host organism

Rabbit (Oryctolagus cuniculus)

 

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

Other name

Anti-ASPP2/p53BP2 Polyclonal

 

Type

Conjugated Primary Antibody

Group

Polyclonals and antibodies

 

Purification method

Purified by Protein A.

Clone

Polyclonal Antibodies

 

Clonality

Polyclonal Antibody

Applications with corresponding dilutions

IF(IHC-P)(1:50-200)

 

Subcellular locations

Cytoplasm, Nucleus

Conjugated with

ALEXA FLUOR® 594

 

Conjugated

Alexa conjugate 1

Target Protein/Peptide

ASPP2/p53BP2

 

Concentration

1ug per 1ul

Excitation emission

590nm/617nm

 

Applications

IF(IHC-P)

Swiss Prot

Q13625

 

Modification site

None

Gene ID

7159