Anti-P53(Ser33) (Polyclonal), ALEXA Fluor 594

The best Anti-P53(Ser33) (Polyclonal), ALEXA Fluor 594, quick delivery, high quality.

Product price

516 EUR

Product size

100 microliters

Product catalog no.


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Background information

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.


Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.


Cross Reactive Species details

No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.


Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.



This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.


P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53



Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Antigen Source

KLH conjugated synthetic phosphopeptide derived from human P53 around the phosphorylation site of Ser33



This antibody reacts specifically with P53(Ser33)


For facs or microscopy Alexa 1 conjugate.


Host organism

Rabbit (Oryctolagus cuniculus)

Also known as

P53(Ser33) Polyclonal Antibody



Alexa Fluor,ALEXA FLUOR® 594


Conjugated Primary Antibody



Polyclonals and antibodies

Other name

Anti-P53(Ser33) Polyclonal


Purification method

Purified by Protein A.


Polyclonal Antibodies


Cross reactive species

Human (Homo sapiens)


Polyclonal Antibody


Applications with corresponding dilutions


Subcellular locations

Cytoplasm, Nucleus



Alexa conjugate 1

Conjugated with





Excitation emission




1ug per 1ul

Target Protein/Peptide

P53 Ser33




Swiss Prot



Modification site


Gene ID