p53 (AF2C1) Monoclonal Antibody

The best quality, top p53 (AF2C1) Monoclonal Antibody prices, fast delivery.

Product price

362 EUR

Product size

0.1ml

Product catalog no.

bsm-50362M

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Background of the target antigen

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

 

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

 

Synonym names

P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

 

Source

Recombinant human protein purified from E.coli (His-p53)

Specificity

This is a highly specific antibody against p53.

 

Also known as

p53 (AF2C1) Monoclonal Antibody

Long name

p53 (AF2C1) Monoclonal Antibody

 

Recommended dilutions

WB (0.5 ug/ml) IP (2.0 ug)

Purification method

Purified by Protein G.

 

Modification site(s)

Unmodified antibody

Category

Primary Antibodies

 

Conjugation

Unconjugated

Concentration

1ug per 1ul

 

Clonality

Monoclonal

French translation

anticorps

 

Tested Applications

WB, IP

Swiss Prot

P04637

 

Cross reactivity

Human

Clone number

AF2C1

 

Modification(s)

None

Gene ID number

7157

 

Target Antigen

p53