TP53 Antibody

The best quality, top TP53 Antibody prices, fast delivery.

Product price

406 EUR

Product size

0.4 ml

Product catalog no.

F52117-0.4ML

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Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Storage

Aliquot the TP53 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.

 

Species reactivity

Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.

Properties

If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

 

Notes

Titration of the TP53 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 314-342 from the human protein was used as the immunogen for this TP53 antibody.

 

Intented use

This TP53 antibodyis to be used only for research purposes and not for diagnostics..

Concentration

In 1X PBS, pH 7.4, with 0.09% sodium azide

 

Host animal

Rabbit (Oryctolagus cuniculus)

Clonality

Polyclonal (rabbit origin)

 

Form

Antigen affinity purified

Recommended dilutions

Western blot: 1:1000

 

Clone

Polyclonal antibody

Purity

Antigen affinity

 

Conjugation

Unconjugated

French translation

anticorps

 

Tested applications

WB, ELISA

Category

Antibody

 

Uniprot #

P04637

Recognised antigen

TP53