TP53 Polyclonal Antibody

The best TP53 Polyclonal Antibody, quick delivery, high quality.

Product price

401 EUR

Product size

100 μg

Product catalog no.

CAC07006

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Supplementary information

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediatedapoptosis.

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

 

Properties

If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Other name

Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53,TP53,P53

 

Verified applications

ELISA,WB,IHC. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200

Immunogen

Recombinant human Cellular tumor antigen p53 protein (2-393AA)

 

Storage recommendation

Aliquot and store at -20°C. Minimize freezing and thawing.

Notes

For research use only. Not for diagnostic procedures.

 

Purity

Caprylic Acid Ammonium Sulfate Precipitation Purified

Group

Polyclonals and antibodies

 

Gene number

Please refer to GenBank

NCBI number

Please refer to NCBI

 

Estimated production time

3-7 business days

Verified reactivity

Human, Mouse

 

Clonality

Polyclonal

French translation

anticorps

 

Shipping requirements

Blue ice

Protein number

P04637

 

Use before

1 year

Raised in

Rabbit