P53(wt-p53) (D2F7) Monoclonal Antibody, ALEXA FLUOR 488

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Product price

380 EUR

Product size

100ul

Product catalog no.

bsm-2346M-A488

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Background of the antigen

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-P53wt-p53 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

 

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

Synonyms

Widespread p53; Wtp53; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC11998; LFS1; p53; p53 Cellular Tumor Antigen; p53 Tumor Suppressor; Phosphoprotein p53; TP53; Transformation related protein 53; TRP53; Tumor protein p53; Tumour Protein p53; P53_HUMAN; TP53.

 

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human P53(wt-p53)

 

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Long name

P53(wt-p53) (D2F7) Monoclonal Antibody, ALEXA FLUOR 488 Conjugated

 

Specificity

This is a highly specific antibody against P53wt-p53.

Also known as

Anti-P53wt-p53 MAb ALEXA FLUOR 488

 

Category

Conjugated Primary Antibodies

Purification

Purified by Protein G.

 

Host Organism

Mouse (Mus musculus)

Recommended dilutions

IF(IHC-P)(1:50-200)

 

Conjugated with

ALEXA FLUOR® 488

Conjugation

Alexa Fluor

 

Excitation emission

499nm/519nm

Concentration

1ug per 1ul

 

Modification

Unmodified

Clonality

Monoclonal

 

Crossreactivity

Human, Rat

French translation

anticorps

 

Tested applications

IF(IHC-P)

Target Antigen

P53wt-p53

 

Clone

D2F7

Modification Site

None

 

Gene ID Number

7157