P53(Ser392) Antibody, ALEXA FLUOR 555

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Product price

350 EUR

Product size

100ul

Product catalog no.

bs-1650R-A555

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Background of the antigen

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Properties

For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

 

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Synonyms

P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53

 

Source

KLH conjugated synthetic phosphopeptide derived from human p53 around the phosphorylation site of (Ser392)

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

 

Long name

P53(Ser392) Polyclonal Antibody, ALEXA FLUOR 555 Conjugated

Specificity

This is a highly specific antibody against P53 Ser392.

 

Also known as

Anti-P53 Ser392 PAb ALEXA FLUOR 555

Host Organism

Rabbit (Oryctolagus cuniculus)

 

Category

Conjugated Primary Antibodies

Conjugation

Alexa Fluor,ALEXA FLUOR 555

 

Purification

Purified by Protein A.

Clone

Polyclonal antibody

 

Recommended dilutions

IF(IHC-P)(1:50-200)

Conjugated with

ALEXA FLUOR® 555

 

Modification

Phosphorylation

Immunogen range

382-393/393

 

Excitation emission

553nm/568nm

Concentration

1ug per 1ul

 

Clonality

Polyclonal

Target Antigen

P53 Ser392

 

French translation

anticorps

Tested applications

IF(IHC-P)

 

Swiss Prot

P04637

Modification Site

Ser392

 

Crossreactivity

Human

Gene ID Number

7157