P53(Ser315) Antibody, ALEXA FLUOR 350

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Product price

350 EUR

Product size

100ul

Product catalog no.

bs-3704R-A350

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Background of the antigen

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

 

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Synonyms

P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53

 

Source

KLH conjugated synthetic phosphopeptide derived from human P53 around the phosphorylation site of Ser315

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

 

Long name

P53(Ser315) Polyclonal Antibody, ALEXA FLUOR 350 Conjugated

Specificity

This is a highly specific antibody against P53 Ser315.

 

Also known as

Anti-P53 Ser315 PAb ALEXA FLUOR 350

Host Organism

Rabbit (Oryctolagus cuniculus)

 

Category

Conjugated Primary Antibodies

Conjugation

Alexa Fluor,ALEXA FLUOR 350

 

Purification

Purified by Protein A.

Recommended dilutions

IF(IHC-P)(1:50-200)

 

Clone

Polyclonal antibody

Subcellular location

Cytoplasm, Nucleus

 

Conjugated with

ALEXA FLUOR® 350

Modification

Phosphorylation

 

Excitation emission

343nm/442nm

Immunogen range

280-330/393

 

Concentration

1ug per 1ul

Target Antigen

P53 Ser315

 

Clonality

Polyclonal

Tested applications

IF(IHC-P)

 

French translation

anticorps

Modification Site

Ser315

 

Swiss Prot

P04637

Crossreactivity

Human

 

Gene ID Number

7157