The best anti-p53 (phospho Ser37) Antibody, quick delivery, high quality.
180 EUR
0.1 mg
79-448
p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
p53 (Phospho-Ser37) antibody was made against a peptide sequence around phosphorylation site of serine 37 (L-P-S (p) -Q-A) derived from Human p53.
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
P53, BCC7, LFS1, TRP53, GAD, GAD67, Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13, TP53
This antibody detects endogenous level of p53 only when phosphorylated at serine 37.
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Store antibody at -20 grades C for up to one year.
Western Blot, immuno fluorescence
tumor protein p53
Human, Mouse, Rat
unlabelled serum
Homo sapiens
NP_000537.3
in solution
Polyclonal
120407068
anticorps
1 mg/mL
P04637
53 kDa
Rabbit
TP53
7157