Rabbit Anti Human TP53INP1 Antibody-Non-conjugated

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Product price

212 EUR

Product size

50ug

Product catalog no.

CSB-PA822174LA01HU_50ug

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Background

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Properties

If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

 

About

Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.

Shipping and storage

TP53INP1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.

 

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.

Alias

Tumor protein p53-inducible nuclear protein 1,Stress-induced protein,p53-dependent damage-inducible nuclear protein 1,p53DINP1,TP53INP1,P53DINP1,SIP

 

Immunogen type

Recombinant Human Tumor protein p53-inducible nuclear protein 1 protein (138-205AA)

Buffer composition

Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

 

Tested applications & recommended dilutions

ELISA,IHC,IF;Recommended dilution:IHC:1:20-1:200,IF:1:50-1:200

Long name

Rabbit Antibody against Human TP53INP1, Non-conjugated

 

Short name of the antigen

Tumor protein p53-inducible nuclear protein 1

Format

Liquid, diluted in buffer

 

Synonym name

TP53INP1 Human Antibody

Antibody category

Polyclonal Antibodies

 

Latin name

Oryctolagus cuniculus

Clonality

Polyclonal antibody

 

Purification method

Protein G purified

Conjugation

Non-conjugated

 

French translation

anticorps

UniProt ID

Q96A56

 

Immunogen species

Human

Species reactivity

Human

 

Purity

>95%

Antibody isotype

IgG